李连，博士，山东大学药学院副研究员，硕士研究生导师。主要研究领域包括：（1）基于振动光谱的药物生产过程关键质量属性在线表征的基础理论与应用研究；（2）基于振动光谱的药物筛选与评价技术研究。其中，在药物生产过程分析方面，开展基于近红外光谱、中红外光谱以及拉曼光谱的药物生产过程中关键质量属性的表征及融合表征研究；在药物提取、浓缩等环节，开展基于水光谱技术的提取过程、浓缩等过程的质量可视化表征研究；在药物筛选与评价方面，主要开展基于无标记振动光谱的快速评价研究。

基于以上研究方向，近5年来先后主持国家自然基金青年基金1项、国家重点研发计划子课题1项、中国博士后科学基金面上基金1项、山东省博士后创新基金1项，参与国家重大新药创制专项、山东省重大创新工程等多项国家级、省部级课题。研究成果在Carbohydrate Polymer，Materials Science and Engineering: C，International Journal of Molecular Sciences，Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy等杂志发表，参与授权发明专利10余项，软件著作权1项。多次在近红外光谱学术会议做报告，获得2019年国际近红外光谱学会John Shenk Travel Grants，2021年The 4th Aquaphotomics International Symposium最佳墙报奖。在中国科协项目中主要承担近红外光谱分析技术在制药过程中应用的分析方法、药典相应要求的方法解读等科普性工作。

近期发表代表性文章：

[1] Chen Yu, Hengchang Zang, Cui Yang, Dong Liang, Shuang Quan, Danyang Li, Yanni Li, Qin Dong, Fengshan Wang,Lian Li*. Study of chondroitin sulfate E oligosaccharide as a promising complement C5 inhibitor for osteoarthritis alleviation, Materials Science and Engineering: C, 2021,112234.

[2] Chen Yu#, Bing Zhao#, Yan Li, Hengchang Zang,Lian Li*. Vibrational Spectroscopy in Assessment of Early Osteoarthritis—A Narrative Review. International Journal of Molecular Sciences. 2021; 22(10):5235.

[3] Mengqi Zhang, Liang Liu, Cui Yang, Zhongyu Sun, Xiuhua Xu,Lian Li*, and Hengchang Zang*, Research on the Structure of Peanut Allergen Protein Ara h1 Based on Aquaphotomics. Frontiers in Nutrition, 2021. 8(311).

[4] Chen Yu#, Shuang Quan#, Cui Yang, Chengliang Zhang, Jiajin Fan,Lian Li*, and Hengchang Zang*, Determination of the immunoglobulin G precipitation end-point by an intelligent near-infrared spectroscopy system. Journal of Innovative Optical Health Sciences, 2021: p. 2150007.

[5] Lanling Liu, Kefan Zhang, Zhongyu Sun, Qin Dong,Lian Li*, and Hengchang Zang*, A new perspective in understanding the dissolution behavior of nifedipine controlled release tablets by NIR spectroscopy with aquaphotomics. Journal of Molecular Structure, 2021. 1230: p. 129872.

[6] Lele Gao, Liang Zhong, Jin Zhang, Mengqi Zhang, Yingzi Zeng,Lian Li*, and Hengchang Zang*, Water as a probe to understand the traditional Chinese medicine extraction process with near infrared spectroscopy: A case of Danshen (Salvia miltiorrhiza Bge) extraction process. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021. 244: p. 118854.

[7] Liang Zhong, Lele Gao,Lian Li*, Hengchang Zang*. Trends-process analytical technology in solid oral dosage manufacturing. European journal of pharmaceutics and biopharmaceuticsk,2020, (153): 187-199.

[8] Lian Li#, Shuang Quan#, Danyang Li, Jiayue Wang, Hengchang Zang*, Lining Zhang*, Development of near infrared spectroscopy methodology for human albumin determination using a new calibration approach. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2019 (217), 56-262.

[9] Li Lian, Li Yan, Feng Danyang, Xu Linghua, Yin Fengxin, Zang Hengchang, Liu Chunhui, Wang Fengshan*, Preparation of low molecular weight chondroitin sulfates, screening of a high anti-complement capacity of low molecular weight chondroitin sulfate and its biological activity studies in attenuating osteoarthritis, International Journal of Molecular Sciences, 2016, 17(10):1685

[10] Li Lian, Li Yan, Ijaz Muhammad, Shahbaz Muhammad, Lian Qianqian, Wang Fengshan*, Review on complement analysis method and the roles of glycosaminoglycans in the complement system, Carbohydrate polymers, 2015, 134: 590-597